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Worksheet C03a - Sethoxydim Risk Assessment

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Worksheet C03a:

 Accidental Spill onto the Hands for 1 Hour Based on the Assumption of First-Order 
Absorption [WrkDrmFrHnd] 
Verbal Description: A worker spills a solution of the compound at a specified concentration (

C

) on a defined 
area of the skin (

A

).  Based on the amount of liquid adhering to the skin (

L

), the amount of chemical absorbed 
(

Dose

) over a given period is calculated from the first order dermal absorption coefficient (

k


a


), the amount of 
time that the chemical remains on the surface of the skin before it is effectively removed by washing  (

T

) and 
the body weight (

W

) (Durkin et al. 1995). 
Parameter 
Value 
Units 
Source 
Liquid adhering to skin after a spill (

L


0.008 
mL/cm

STD.Liq 
Body weight (

W


70 
kg 
STD.BW 
Surface Areas (

A


Hands 
840 
cm

STD.Hands 
Duration of Exposure (

T



hours 
First-order dermal absorption rates (

k


a



Central 
0.00110 
hour
-1 
DERM.ABSC 
Lower 
0.000470 
DERM.ABSL 
Upper 
0.00250 
DERM.ABSU 
Concentration in solution (

C


Central 
3.6 
mg/mL 
APPL.TypDr 
Lower 
0.56 
APPL.LowDr 
Upper 

APPL.HI_Dr 
Amount Deposited on Skin (

Amnt

): L × A × C 
Central 
24.192 
mg 
Lower 
3.7632 
Upper 
60.48 
Proportion absorbed over period 

T

 (

Prop

): 1-e
-k T 
Central 
0.0010994 
unitless 
Lower 
0.0004699 
Upper 
0.0024969 
Absorbed Dose (D
Abs
): 

Amnt × Prop

 ÷ 


Central 
3.80e-04 
mg/kg bw 
Lower 
2.53e-05 
Upper 
2.16e-03 
WS-23  

Worksheet C03b: Accidental Spill onto the Lower Legs for 1 Hour Based on the Assumption of First-


Order Absorption [WrkDrmFrLeg] 


Verbal Description: A worker spills a solution of the compound at a specified concentration (

C

) on a defined 
area of the skin (

A

).  Based on the amount of liquid adhering to the skin (

L

), the amount of chemical absorbed 
(

Dose

) over a given period is calculated from the first order dermal absorption coefficient (

k


a


), the amount of 
time that the chemical remains on the surface of the skin before it is effectively removed by washing  (

T

) and 
the body weight (

W

) (Durkin et al. 1995). 
Parameter 
Value 
Units 
Source 
Liquid adhering to skin after a spill (

L


0.008 
mL/cm

STD.Liq 
Body weight (

W


70 
kg 
STD.BW 
Surface Areas (

A


Legs 
2070 
cm

STD.LLegs 
Duration of Exposure (

T



hours 
First-order dermal absorption rates (

k


a



Central 
0.00110 
hour
-1 
DERM.ABSC 
Lower 
0.000470 
DERM.ABSL 
Upper 
0.00250 
DERM.ABSU 
Concentration in solution (

C


Central 
3.6 
mg/mL 
APPL.TypDr 
Lower 
0.56 
APPL.LowDr 
Upper 

APPL.HI_Dr 
Amount Deposited on Skin (

Amnt

): L × A × C 
Central 
59.616 
mg 
Lower 
9.2736 
Upper 
149.04 
Proportion absorbed over period 

T

 (

Prop

): 1-e
-k T 
Central 
0.0010994 
unitless 
Lower 
0.0004699 
Upper 
0.0024969 
Absorbed Dose (D
Abs
): 

Amnt × Prop

 ÷ 


Central 
9.36e-04 
mg/kg bw 
Lower 
6.23e-05 
Upper 
5.32e-03 
WS-24  

EXPOSURE ASSESSMENTS FOR THE GENERAL PUBLIC

 

Worksheet D01a: Direct Spray of a Child,  Assumption of First-Order Absorption [SpillFOACh01]

 

Verbal Description

: A naked child is accidentally sprayed over the entire body surface (

A

) with a field dilution 
of a specified concentration (

C

).  The child is effectively washed - i.e., all of the compound is removed - after a 
specified period of time (

T

).  The absorbed dose (

D

) is calculated from the amount of liquid adhering to the skin 
(

L

), the first-order dermal absorption rate (

k


a


) and the body weight (

W

). 
Parameter 
Value 
Units 
Source 
Liquid adhering to skin after a spill (

L


0.008 
mL/cm

STD.Liq 
Body weight (

W


13.3 
kg 
PUBL.BWC 
Exposed surface area (

A


Whole Body 
6030 
cm

PUBL.SAC 
Duration of Exposure (

T



hours 
First-order dermal absorption rates (

k


a



Central 
0.00110 
hour
-1 
DERM.ABSC 
Lower 
0.000470 
DERM.ABSL 
Upper 
0.00250 
DERM.ABSU 
Concentration in solution (

C


Central 
3.6 
mg/mL 
APPL.TypDr 
Lower 
0.56 
APPL.LowDr 
Upper 

APPL.HI_Dr 
Amount Deposited on Skin (

Amnt

): L × A × C 
Central 
173.664 
mg 
Lower 
27.0144 
Upper 
434.16 
Proportion absorbed over period 

T

 (

Prop

): 1-e
-k T 
Central 
0.0010994 
unitless 
Lower 
0.0004699 
Upper 
0.0024969 
Absorbed Dose (D
Abs
): 

Amnt × Prop

 ÷ 


Central 
1.44e-02 
mg/kg bw 
Lower 
9.54e-04 
Upper 
8.15e-02 
WS-25  


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